The shift in the US government to increase the product delivery to meet the speed of relevance has required industry to move to Agile and DevOps to deliver products and services. The Majority of the systems Lockheed Martin and Northrop Grumman build require us to scale Agile up as well as to integrate Hardware, Software, Firmware for highly regulated environments. This talk will discuss the transition of multiple legacy programs. We plan to provide examples and a blueprints to implement what we have coined as Industrial DevSecOps within similar environments. We will deep dive into the details of how to manage long lead items, contracts, supply chain, multiple vendors, dependencies, and risk for systems that are safety critical and support the security of the country.